| Registro completo |
| Provedor de dados: |
Ciência e Agrotecnologia
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| País: |
Brazil
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| Título: |
Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi
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| Autores: |
Paiva,Rojane de Oliveira
Kneipp,Lucimar Ferreira
Goular,Carla Marins
Albuquerque,Mariana Almeida
Echevarria,Aurea
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| Data: |
2014-12-01
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| Ano: |
2014
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| Palavras-chave: |
Aspergillus
Fusarium
Mycotoxicology
Thiosemicarbazones
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| Resumo: |
Mycotoxigenic fungi can compromise the quality of food, exposing human and animal health at risk. The antifungal activity of eight thiosemicarbazones (1-8) and nine semicarbazones (9-17) was evaluated against Aspergillus flavus, A. nomius, A. ochraceus, A. parasiticus and Fusarium verticillioides. Thiosemicarbazones had MIC values of 125-500 µg/ml. The thiosemicarbazones 1 and 2 exerted fungistatic activity against Aspergillus spp., and thiosemicarbazone 2 exerted fungicidal activity against F. verticillioides. Compound 2 showed an iron chelating effect of 63%. The ergosterol content of A. parasiticus had a decrease of 28 and 71% for the 31.2 and 62.5 µg/ml concentrations of thiosemicarbazone 2 compared to the control. The obtained results of antifungal activity revealed that thiosemicarbazone class was more active when compared to semicarbazone class and, the thiosemicarbazone 2 was the most active compound, specially, against Aspergillus spp.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542014000600001
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| Editor: |
Editora da Universidade Federal de Lavras
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| Relação: |
10.1590/S1413-70542014000600001
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| Formato: |
text/html
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| Fonte: |
Ciência e Agrotecnologia v.38 n.6 2014
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| Direitos: |
info:eu-repo/semantics/openAccess
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